




Desvenlafaxine
Desvenlafaxine is a non-hormonal prescription medication in the SNRI family (serotonin-norepinephrine reuptake inhibitor). In menopause care, SNRIs are used to help reduce vasomotor symptoms (VMS) such as hot flashes and night sweats, especially for women who prefer to avoid hormones or who are not candidates for hormone therapy
Active ingredients
Desvenlafaxine (extended-release tablet).
How to take
Take once daily, at the same time each day. Swallow extended-release tablets whole (don’t crush, chew, or dissolve). For menopause VMS, NAMS lists a suggested SNRI dosing range for desvenlafaxine 100–150 mg/day, with a start at 25–50 mg/day and titrate up (clinician-guided). If you miss a dose: take your next dose at the usual time—don’t double.
Potential side effects
Common side effects with SNRIs can include:
- nausea, constipation/dry mouth
- dizziness
- sleep changes
- sweating
- decreased appetite or weight changes
- sexual side effects





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