If you’re not losing weight on semaglutide, the situation is usually solvable—but it requires a structured review rather than guesswork. Weight loss can stall for reasons that have nothing to do with “willpower.”

Common reasons progress slows

• You’re early in treatment: appetite and behavior changes can take time to stabilize.
• Calorie intake hasn’t changed enough: reduced appetite doesn’t always mean sustained deficit.
• Meal quality is low-satiety: small portions of high-calorie foods can stall progress.
• Under-eating: severe restriction can be hard to sustain and may increase cravings.
• Low movement: even modest increases in walking can shift energy balance.
• Stress and sleep: both influence cravings and eating behavior.
• Plateau physiology: weight loss often slows as the body adapts.

What to do next

1. Track meals for 5–7 days (no judgment—just data).
2. Prioritize protein and fiber to support satiety.
3. Add consistent movement (daily walk + basic strength work).
4. Review side effects that might be limiting food quality (nausea, constipation).
5. Contact your clinician if no progress after several weeks.

Clinician review matters

If you’re stalled, a clinician can evaluate whether the plan needs adjustment and screen for issues that require medical attention. Avoid self-adjusting dosing.

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If you’re still hungry on tirzepatide, it doesn’t automatically mean treatment “isn’t working.” Hunger can change week to week, and several fixable factors may be involved.

Common reasons hunger persists

• You’re early in treatment: appetite effects may build over time.
• Meal composition is too light on protein/fiber: smaller meals can unintentionally become low-satiety meals.
• Dehydration or poor sleep: both can mimic hunger signals.
• High-stress weeks: stress can increase cravings and snack behavior.
• You’re under-eating: severe restriction can backfire, increasing hunger and reducing adherence.

What to try before you panic

• Eat protein first at meals, then add fiber (cooked vegetables, beans, oats).
• Hydrate consistently; set a daily minimum goal.
• Add a structured snack if you’re getting “late-day hunger crashes.”
• Track patterns for one week (dose day, hunger timing, meals).

When to contact your clinician

If hunger remains high for multiple weeks, or weight and appetite trends move in an unexpected direction, contact your care team. Dose adjustments and plan changes require clinician oversight—do not self-adjust.

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Tirzepatide Safety Information

Who it’s for

Tirzepatide-based therapy may be used in clinician-guided programs for chronic weight management in appropriate patients, alongside nutrition and physical activity changes.

Who should not use

A clinician must screen for contraindications and risk factors. Patients should disclose current medications, past adverse reactions, pregnancy status, and relevant family history.

Warnings

Patients must know what symptoms require immediate medical attention (severe or persistent vomiting, dehydration signs, severe abdominal pain, allergic reactions), and how to reach your clinical support.

Compounded disclosures

If compounded: state clearly that compounded drugs are not FDA-approved and are not evaluated by the FDA for safety, effectiveness, or quality prior to marketing.

How to get help

If medication is provided in a vial, dosing errors are a known risk when patients measure doses themselves. Provide a step-by-step injection basics guide, measurement safety reminders, and “contact your clinician if unsure” instructions.

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